Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels

Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels

Serine proteases (SPs) play physiological roles in the kidney. We previously reported that a synthetic SP inhibitor, camostat mesilate (CM), suppressed sodium reabsorption in the renal tubule and showed natriuretic effects in aldosterone-infused rats. Here, we aimed to explore novel physiological ro...

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Bibliographic Details
Main Authors: Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Qinyuan Deng, Masataka Adachi, Yoshikazu Miyasato, Miyuki Nakagawa, Yu Nagayoshi, Kayo Nishiguchi, Yuki Narita, Yuichiro Izumi, Takashige Kuwabara, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Serine protease
Camostat mesilate
Water diuresis
AQP2
Exosome
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000706

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http://www.sciencedirect.com/science/article/pii/S1347861322000706

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