Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa

Characterization of the dispirotripiperazine derivative PDSTP as antibiotic adjuvant and antivirulence compound against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major human pathogen, able to establish difficult-to-treat infections in immunocompromised and people with cystic fibrosis (CF). The high rate of antibiotic treatment failure is due to its notorious drug resistance, often mediated by the formation of persistent biofilms....

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Bibliographic Details
Main Authors: Andrea Bonacorsi, Gabriele Trespidi, Viola C. Scoffone, Samuele Irudal, Giulia Barbieri, Olga Riabova, Natalia Monakhova, Vadim Makarov, Silvia Buroni
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
drug resistance
antibiotic adjuvant
combination therapy
antivirulence
antiadhesion
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1357708/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1357708/full

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