Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells

Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells

Background : Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. Methods : Using human renal tubule cells HK-2, we assessed the impact of high glucose (HG) on autophagy....

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Bibliographic Details
Main Authors: Joo-Heon Kim, Kyeong Min Kim, Jin Uk Jeong, Jong Ho Shin, Jae Min Shin, Ki Tae Bang
Format: Article
Language:English
Published: The Korean Society of Nephrology 2019-09-01
Series:Kidney Research and Clinical Practice
Subjects:
Autophagy
Diabetic nephropathies
Heme oxygenase-1
Nrf2
Sulforaphane
Online Access:https://doi.org/10.23876/j.krcp.18.0152

Internet

https://doi.org/10.23876/j.krcp.18.0152

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