Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine

Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine

A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly pleasurable experience initially associated with the consumption of the drug. We have recently found that members of the CPEB family of proteins (...

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Bibliographic Details
Main Authors: Bettina Drisaldi, Luca Colnaghi, Amir Levine, YanYou Huang, Anna M. Snyder, Daniel J. Metzger, Martin Theis, Denise B. Kandel, Eric R. Kandel, Luana Fioriti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cytoplasmic polyadenylation
protein translation
cocaine
addictive behavior
delta FosB
FosB
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00207/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00207/full

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