The p53–53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure

The p53–53BP1-Related Survival of A549 and H1299 Human Lung Cancer Cells after Multifractionated Radiotherapy Demonstrated Different Response to Additional Acute X-ray Exposure

Radiation therapy is one of the main methods of treating patients with non-small cell lung cancer (NSCLC). However, the resistance of tumor cells to exposure remains the main factor that limits successful therapeutic outcome. To study the molecular/cellular mechanisms of increased resistance of NSCL...

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Bibliographic Details
Main Authors: Margarita Pustovalova, Lina Alhaddad, Nadezhda Smetanina, Anna Chigasova, Taisia Blokhina, Roman Chuprov-Netochin, Andreyan N. Osipov, Sergey Leonov
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
non-small cell lung cancer
ionizing radiation
radioresistance
DNA repair
p53
Online Access:https://www.mdpi.com/1422-0067/21/9/3342

Internet

https://www.mdpi.com/1422-0067/21/9/3342

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