Single cell sequencing analysis identifies genetics-modulated ORMDL3 + cholangiocytes having higher metabolic effects on primary biliary cholangitis

Single cell sequencing analysis identifies genetics-modulated ORMDL3 + cholangiocytes having higher metabolic effects on primary biliary cholangitis

Abstract Background Primary biliary cholangitis (PBC) is a classical autoimmune disease, which is highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous genetic loci were significantly associated with PBC susceptibility. However, the effect...

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Bibliographic Details
Main Authors: Bingyu Xiang, Chunyu Deng, Fei Qiu, Jingjing Li, Shanshan Li, Huifang Zhang, Xiuli Lin, Yukuan Huang, Yijun Zhou, Jianzhong Su, Mingqin Lu, Yunlong Ma
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Nanobiotechnology
Subjects:
Single cell sequencing analysis
GWAS
Risk genes
PBC
ORMDL3
Liver cells
Online Access:https://doi.org/10.1186/s12951-021-01154-2

Internet

https://doi.org/10.1186/s12951-021-01154-2

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