The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation

The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation

Abstract Background Promoters are sites of transcription initiation that harbour a high concentration of phenotype-associated genetic variation. The evolutionary gain and loss of promoters between species (collectively, termed turnover) is pervasive across mammalian genomes and may play a prominent...

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Bibliographic Details
Main Authors: Robert S. Young, Lana Talmane, Sophie Marion de Procé, Martin S. Taylor
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Genome Biology
Subjects:
Promoter
Evolution
Transcription regulation
Molecular phenotype
QTL
Trait
Online Access:https://doi.org/10.1186/s13059-022-02634-w

Internet

https://doi.org/10.1186/s13059-022-02634-w

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