Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model

Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model

Chemoprevention of hepatocellular carcinoma (HCC) is highly desirable in clinic. Berberine (BBR) is reported to play potential roles in cancer treatment and prevention. We studied the chemopreventive effect of BBR on hepatocellular carcinogenesis in an inflammation-driven mouse model, as it was enri...

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Bibliographic Details
Main Authors: Gang Ren, Jiang-Hong Guo, Chen-Lin Feng, Yu-Wei Ding, Biao Dong, Yan-Xing Han, Yu-Huan Li, Lu-Lu Wang, Jian-Dong Jiang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
hepatocellular carcinoma
berberine
LPA receptor-2
autotaxin
leptin
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001000

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http://www.sciencedirect.com/science/article/pii/S2372770522001000

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