CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease

Abstract Background Despite its identification as a key checkpoint regulator of microglial activation in Alzheimer’s disease, the overarching role of CX3CR1 signaling in modulating mechanisms of Aβ driven neurodegeneration, including accumulation of hyperphosphorylated tau is not well understood. Me...

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Bibliographic Details
Main Authors: Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth, Bruce T. Lamb
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Molecular Neurodegeneration
Subjects:
Amyloid
CX3CR1
Microglia
Neurodegeneration
Tau
Online Access:https://doi.org/10.1186/s13024-022-00545-9

Internet

https://doi.org/10.1186/s13024-022-00545-9

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