Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells

Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells

Background: In animal models of heart failure (HF), heart rate decreases due to an increase in intrinsic cycle length (CL) of the sinoatrial node (SAN). Pacemaker activity of SAN cells is complex and modulated by the membrane clock, i.e., the ensemble of voltage gated ion channels and electrogenic p...

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Bibliographic Details
Main Authors: Arie O. Verkerk, Marcel M.G.J. van Borren, Antoni C.G. Van Ginneken, Ronald eWilders
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Physiology
Subjects:
Action Potentials
Heart Failure
Sinoatrial Node
Sodium-Calcium Exchanger
pacemaker activity
Intracellular Ca2+
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00018/full

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