Model building of protein complexes from intermediate-resolution cryo-EM maps with deep learning-guided automatic assembly
One challenge in cryo-EM is to build atomic models into intermediate resolution maps. Here, the authors present a deep learning-guided iterative assembling method by integrating AlphaFold, FFTbased fitting, and domain-based refinement.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31748-9 |