Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis

Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis

Abstract Background The infrapatellar fat pad (IFP) is implicated in knee osteoarthritis (KOA). Calcitonin gene-related peptide (CGRP), a vasoactive neuropeptide expressed in joint tissues and synovial tissues (ST), was recently found to be associated with KOA progression and pain. CGRP is expressed...

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Bibliographic Details
Main Authors: Jun Aikawa, Kentaro Uchida, Shotaro Takano, Gen Inoue, Dai Iwase, Masayuki Miyagi, Manabu Mukai, Shintaro Shoji, Hiroyuki Sekiguchi, Masashi Takaso
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Lipids in Health and Disease
Subjects:
Calcitonin gene-related peptide/SE
Osteoarthritis, knee
Adipose tissue/PP
Prostaglandin E2
Online Access:http://link.springer.com/article/10.1186/s12944-018-0864-8

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http://link.springer.com/article/10.1186/s12944-018-0864-8

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