A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging

Mitochondrial metabolism is of central importance to diverse aspects of cell and developmental biology. Defects in mitochondria are associated with many diseases, including cancer, neuropathology, and infertility. Our understanding of mitochondrial metabolism in situ and dysfunction in diseases are...

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Bibliographic Details
Main Authors: Xingbo Yang, Gloria Ha, Daniel J Needleman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/73808