Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors. However, this model remains unproven biochemically a...

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Bibliographic Details
Main Authors: Anil M Narasimha, Manuel Kaulich, Gary S Shapiro, Yoon J Choi, Piotr Sicinski, Steven F Dowdy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
cell cycle
Rb tumor suppressor
cyclin D:Cdk4
mono-phosphorylated Rb
p16
G1 phase
Online Access:https://elifesciences.org/articles/02872

Internet

https://elifesciences.org/articles/02872

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