BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication fork protection. Nonsense or frameshift mutations...

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Bibliographic Details
Main Authors: Judit Jimenez-Sainz, Joshua Mathew, Gemma Moore, Sudipta Lahiri, Jennifer Garbarino, Joseph P Eder, Eli Rothenberg, Ryan B Jensen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
dna repair
BRCA2
RAD51
homology-directed repair
variants
hereditary cancer
Online Access:https://elifesciences.org/articles/79183

Internet

https://elifesciences.org/articles/79183

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