Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

The quaternary isoquinoline alkaloids of palmatine (<b>1</b>), berberine (<b>2</b>), and jatrorrhizine (<b>3</b>) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC<sub>50</...

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Bibliographic Details
Main Authors: Jang Hoon Kim, Chong Woon Cho, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung-Cheol Koo, Yun-Chan Hur, Jong Seong Kang, Ik Soo Lee
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Current Issues in Molecular Biology
Subjects:
quaternary isoquinoline alkaloids
soluble epoxide hydrolase
non-competitive inhibitor
molecular simulation
Online Access:https://www.mdpi.com/1467-3045/44/9/294

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https://www.mdpi.com/1467-3045/44/9/294

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