USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP28) has been implicated in tumourigenesis through it...

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Bibliographic Details
Main Authors: E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-10-01
Series:eLife
Subjects:
squamous cell lung cancer
USP28
c-MYC
Online Access:https://elifesciences.org/articles/71596

Internet

https://elifesciences.org/articles/71596

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