Optoplasmonic characterisation of reversible disulfide interactions at single thiol sites in the attomolar regime

Visualising single-molecule reactions, to understand their mechanisms, is a challenging task. Here, the authors investigate disulfide exchange reactions with thiolates immobilised on a gold nanoparticle through a label-free optoplasmonic sensor, and detect individual disulfide interactions in soluti...

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Bibliographic Details
Main Authors: Serge Vincent, Sivaraman Subramanian, Frank Vollmer
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15822-8