Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance

Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance

Probucol has been utilized as a cholesterol-lowering drug with antioxidative properties. However, the impact and fundamental mechanisms of probucol in obesity-related cognitive decline are unclear. In this study, male C57BL/6J mice were allocated to a normal chow diet (NCD) group or a high-fat diet...

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Bibliographic Details
Main Authors: Han-Ming Wu, Yang Vivian Yang, Na-Jun Huang, Li-Ping Fan, Ying-Ying Dai, Ke-Ting Hu, Tian-Yu Tang, Lin Liu, Yue Xu, Dong-Tai Liu, Ze-Xin Cai, Xiao-Yu Niu, Xin-Yi Ren, Zheng-Hao Yao, Hao-Yu Qin, Jian-Zhen Chen, Xi Huang, Cixiong Zhang, Xiang You, Chen Wang, Ying He, Wei Hong, Yu-Xia Sun, Yi-Hong Zhan, Shu-Yong Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Neuroscience
Subjects:
probucol
high-fat diet
spatial cognition
social behavior
redox homeostasis
insulin resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1368552/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1368552/full

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