Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder

Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder

Abstract Obsessive-compulsive disorder (OCD) is a chronic and severe psychiatric disorder for which effective treatment options are limited. Structural and functional neuroimaging studies have consistently implicated the orbitofrontal cortex (OFC) and striatum in the pathophysiology of the disorder....

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Bibliographic Details
Main Authors: Sean C. Piantadosi, Lora L. McClain, Lambertus Klei, Jiebiao Wang, Brittany L. Chamberlain, Sara A. Springer, David A. Lewis, Bernie Devlin, Susanne E. Ahmari
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01290-1

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https://doi.org/10.1038/s41398-021-01290-1

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