Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against <em>Pseudomonas aeruginosa</em> to Clinical Settings

Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against <em>Pseudomonas aeruginosa</em> to Clinical Settings

Pharmacokinetic-pharmacodynamic (PKPD) models have met increasing interest as tools to identify potential efficacious antibiotic dosing regimens in vitro and in vivo. We sought to investigate the impact of diversely shaped clinical pharmacokinetic profiles of meropenem on the growth/killing patterns...

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Bibliographic Details
Main Authors: Iris K. Minichmayr, Suzanne Kappetein, Margreke J. E. Brill, Lena E. Friberg
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antibiotics
Subjects:
PKPD model
time-kill curve
prolonged infusion
continuous infusion
meropenem
beta-lactam
Online Access:https://www.mdpi.com/2079-6382/11/8/1036

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https://www.mdpi.com/2079-6382/11/8/1036

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