A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels

A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels

Phosphatidylinositol 3-kinase (PI3K) is a key regulator of phosphoinositide-dependent signaling in mammalian cells and its dysfunction is related to multiple syndromes, including cancer. By heterologous expression in Saccharomyces cerevisiae, we have developed a humanized yeast system as a tool for...

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Bibliographic Details
Main Authors: Julia María Coronas-Serna, Teresa Fernández-Acero, María Molina, Víctor J. Cid
Format: Article
Language:English
Published: Shared Science Publishers OG 2018-11-01
Series:Microbial Cell
Subjects:
PI3K
p110α
phosphoinositides
Saccharomyces cerevisiae
humanized yeast
heterologous expression
fluorescent reporter
eisosomes
septins
kinase inhibitors
Online Access:http://microbialcell.com/researcharticles/a-humanized-yeast-based-toolkit-for-monitoring-phosphatidylinositol-3-kinase-activity-at-both-single-cell-and-population-levels/

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http://microbialcell.com/researcharticles/a-humanized-yeast-based-toolkit-for-monitoring-phosphatidylinositol-3-kinase-activity-at-both-single-cell-and-population-levels/

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