GAT inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen

GAT inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen

Oxygen breathing at elevated partial pressures (PO2’s) at or more than 3 atmospheres absolute (ATA) causes a reduction in brain γ-aminobutyric acid (GABA) levels that impacts the development of central nervous system oxygen toxicity (CNS-OT). Drugs that increase brain GABA content delay the onset of...

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Bibliographic Details
Main Authors: Ivan T. Demchenko, Hagir B. Suliman, Sergey Y. Zhilyaey, Olga S. Alekseeva, Tatyana F. Platonova, Matthew S. Makowski, Claude A. Piantadosi, Heath G. Gasier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
anti-inflammation
cerebellum
GABA
hippocampus
mitophagy
mitochondrial biogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1062410/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1062410/full

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