<i>Aggregatibacter actinomycetemcomitans</i> Cytolethal Distending Toxin-Induces Cell Cycle Arrest in a Glycogen Synthase Kinase (GSK)-3-Dependent Manner in Oral Keratinocytes

<i>Aggregatibacter actinomycetemcomitans</i> Cytolethal Distending Toxin-Induces Cell Cycle Arrest in a Glycogen Synthase Kinase (GSK)-3-Dependent Manner in Oral Keratinocytes

Cytolethal distending toxins (Cdt) are produced by a diverse group of pathogens. One Cdt-producing organism, <i>Aggregatibacter actinomycetemcomitans</i>, plays a critical role in the pathogenesis of a unique form of periodontitis, formerly referred to as localized aggressive periodontit...

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Bibliographic Details
Main Authors: Bruce J. Shenker, Lisa P. Walker, Ali Zekavat, Jonathon Korostoff, Kathleen Boesze-Battaglia
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
cytolethal distending toxin
<i>Aggregatibacter actinomycetemcomitans</i>
cell cycle arrest
GSK3
apoptosis
DNA damage response
Online Access:https://www.mdpi.com/1422-0067/23/19/11831

Internet

https://www.mdpi.com/1422-0067/23/19/11831

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