Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in h...

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Bibliographic Details
Main Authors: Young Yun Jung, Jong Hyun Lee, Dongwoo Nam, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
icariin
STAT3
apoptosis
multiple myeloma
JAKs
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00531/full

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