Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss

Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss

Bone-resorbing osteoclasts are essential for skeletal remodelling, and the hyperactive formation and function of osteoclasts are common in bone metabolic diseases, especially postmenopausal osteoporosis. Therefore, regulating the osteoclast differentiation is a major therapeutic target in osteoporos...

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Bibliographic Details
Main Authors: Min Ma, Ao-yuan Fan, Zheng Liu, Li-qing Yang, Jun-ming Huang, Zhi-ying Pang, Feng Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
osteoclast
baohuoside I
uPAR
MAPK
NF-kB
RANKL
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.874952/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.874952/full

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