Dysregulated miRNA and mRNA Expression Affect Overlapping Pathways in a Huntington’s Disease Model
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the Huntingtin gene. Transcriptional dysregulation is one of the main cellular processes affected by mutant Huntingtin (mHtt). In this study, we investigate the alterations in miR...
Main Authors: | Nóra Zsindely, Gábor Nagy, Fruzsina Siági, Anita Farkas, László Bodai |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-07-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/24/15/11942 |
Similar Items
-
DNA Methylation in Huntington’s Disease
by: Nóra Zsindely, et al.
Published: (2021-11-01) -
Acetylation State of Lysine 14 of Histone H3.3 Affects Mutant Huntingtin Induced Pathogenesis
by: Anikó Faragó, et al.
Published: (2022-12-01) -
Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in <i>Drosophila</i> Huntington’s Disease Model
by: Olga I. Bolshakova, et al.
Published: (2022-12-01) -
Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease
by: Tano, Vincent, et al.
Published: (2023) -
The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington’s Disease Model by Acting on the Expression of Carnitine-Related Genes
by: Carla Bertapelle, et al.
Published: (2022-05-01)