GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.

Bibliographic Details
Main Authors: Jian Wang, Alton B. Farris, Kaiming Xu, Ping Wang, Xiangming Zhang, Duc M. Duong, Hong Yi, Hui-Kuo Shu, Shi-Yong Sun, Ya Wang
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11795

Internet

https://doi.org/10.1038/ncomms11795

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