GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis
GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11795 |
| _version_ | 1828902400564396032 |
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| author | Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang |
| author_facet | Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang |
| author_sort | Jian Wang |
| collection | DOAJ |
| description | GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis. |
| first_indexed | 2024-12-13T16:15:51Z |
| format | Article |
| id | doaj.art-eefed085ba1e4e39ac211c89a889211e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:15:51Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eefed085ba1e4e39ac211c89a889211e2022-12-21T23:38:50ZengNature PortfolioNature Communications2041-17232016-06-017111110.1038/ncomms11795GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesisJian Wang0Alton B. Farris1Kaiming Xu2Ping Wang3Xiangming Zhang4Duc M. Duong5Hong Yi6Hui-Kuo Shu7Shi-Yong Sun8Ya Wang9Department of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityDepartment of Pathology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityDepartment of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityDepartment of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityDepartment of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityEmory Integrated Proteomics Core and Biochemistry DepartmentRobert P. Apkaran Integrated Electron Microscope Core, Emory UniversityDepartment of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityDepartment of Hemotology and Medical Oncology, Emory University School of Medicine and the Winship Cancer InstituteDepartment of Radiation Oncology, Emory University School of Medicine and the Winship Cancer Institute, Emory UniversityGPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.https://doi.org/10.1038/ncomms11795 |
| spellingShingle | Jian Wang Alton B. Farris Kaiming Xu Ping Wang Xiangming Zhang Duc M. Duong Hong Yi Hui-Kuo Shu Shi-Yong Sun Ya Wang GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis Nature Communications |
| title | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis |
| title_full | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis |
| title_fullStr | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis |
| title_full_unstemmed | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis |
| title_short | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis |
| title_sort | gprc5a suppresses protein synthesis at the endoplasmic reticulum to prevent radiation induced lung tumorigenesis |
| url | https://doi.org/10.1038/ncomms11795 |
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