Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains

Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains

Insoluble α-synuclein (αSyn) filaments in brain tissue are a hallmark of Parkinson’s disease (PD) and Multiple system atrophy (MSA), and for structural studies, they have for decades been extracted using the detergent sarkosyl. We asked if PD and MSA patient-derived αSyn filament strains display dif...

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Bibliographic Details
Main Authors: Hjalte Gram, Vasileios Theologidis, Thomas Boesen, Poul Henning Jensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
α-synuclein
aggregates
strains
sarkosyl
solubility
seeding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1177556/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1177556/full

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