Sarkosyl differentially solubilizes patient-derived alpha-synuclein fibril strains
Insoluble α-synuclein (αSyn) filaments in brain tissue are a hallmark of Parkinson’s disease (PD) and Multiple system atrophy (MSA), and for structural studies, they have for decades been extracted using the detergent sarkosyl. We asked if PD and MSA patient-derived αSyn filament strains display dif...
Main Authors: | Hjalte Gram, Vasileios Theologidis, Thomas Boesen, Poul Henning Jensen |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-08-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1177556/full |
Similar Items
-
Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride
by: Srinivas Rao Mynenivenkatasatya, et al.
Published: (2020-10-01) -
The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
by: Asad Jan, et al.
Published: (2021-08-01) -
Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
by: Louise Berkhoudt Lassen, et al.
Published: (2022-11-01) -
Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration
by: Mantas Ziaunys, et al.
Published: (2021-11-01) -
Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
by: Simona S. Ghanem, et al.
Published: (2021-06-01)