Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation

Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation

Abstract Transcription termination factor ρ is a hexameric, RNA-dependent NTPase that can adopt active closed-ring and inactive open-ring conformations. The Sm-like protein Rof, a homolog of the RNA chaperone Hfq, inhibits ρ-dependent termination in vivo but recapitulation of this activity in vitro...

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Bibliographic Details
Main Authors: Nelly Said, Mark Finazzo, Tarek Hilal, Bing Wang, Tim Luca Selinger, Daniela Gjorgjevikj, Irina Artsimovitch, Markus C. Wahl
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47439-6

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https://doi.org/10.1038/s41467-024-47439-6

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