Lack of Nck1 protein and Nck-CD3 interaction caused the increment of lipid content in Jurkat T cells

Abstract Background The non-catalytic region of tyrosine kinase (Nck) is an adaptor protein, which is ubiquitously expressed in many types of cells. In T cells, the Nck1 isoform promotes T cell receptor signalling as well as actin polymerisation. However, the role of Nck1 in the lipid metabolism in...

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Main Authors: Aussanee Nuiyen, Araya Rattanasri, Piyamaporn Wipa, Sittiruk Roytrakul, Apirath Wangteeraprasert, Sutatip Pongcharoen, Jutaporn Ngoenkam
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Molecular and Cell Biology
Subjects:
Online Access:https://doi.org/10.1186/s12860-022-00436-3