Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer

Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer

Abstract Background The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive GC are unclear, making it difficult to develop and optimize CLDN18.2-t...

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Bibliographic Details
Main Authors: Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Medicine
Subjects:
Gastric cancer
CLDN18.2
Tumor microenvironment
Immune cell
Prognosis
Online Access:https://doi.org/10.1186/s12916-022-02421-1

Internet

https://doi.org/10.1186/s12916-022-02421-1

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