Effect of 2H and 18O water isotopes in kinesin-1 gliding assay

We show for the first time the effects of heavy-hydrogen water (2H2O) and heavy-oxygen water (H218O) on the gliding speed of microtubules on kinesin-1 coated surfaces. Increased fractions of isotopic waters used in the motility solution decreased the gliding speed of microtubules by a maximum of 21%...

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Bibliographic Details
Main Authors: Andy Maloney, Lawrence J. Herskowitz, Steven J. Koch
Format: Article
Language:English
Published: PeerJ Inc. 2014-03-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/284.pdf