Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

<p>Abstract</p> <p>Background</p> <p>SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells. The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing its proteasomal...

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Bibliographic Details
Main Authors: Brandariz-Nuñez Alberto, Valle-Casuso Jose, White Tommy E, Laguette Nadine, Benkirane Monsef, Brojatsch Jurgen, Diaz-Griffero Felipe
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Retrovirology
Subjects:
SAMHD
Restriction
Nuclear localization
Vpx
HIV-1
SIV
Degradation
Online Access:http://www.retrovirology.com/content/9/1/49

Internet

http://www.retrovirology.com/content/9/1/49

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