Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis

Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis

ORMDL3 is a prominent member of a family of highly conserved endoplasmic reticulum resident proteins, ORMs (ORM1 and ORM2) in yeast, dORMDL in Drosophila and ORMDLs (ORMDL1, ORMDL2, and ORMDL3) in mammals. ORMDL3 mediates feedback inhibition of de novo sphingolipid synthesis. Expression levels of OR...

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Bibliographic Details
Main Authors: Livia Demkova, Viktor Bugajev, Miroslava K. Adamcova, Ladislav Kuchar, Srdjan Grusanovic, Meritxell Alberich-Jorda, Petr Draber, Ivana Halova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
lymphocyte
B cells
sphingolipids
ORMDL proteins
spleen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376629/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1376629/full

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