Formulation, Characterization, and In Vitro/In Vivo Efficacy Studies of a Novel Liposomal Drug Delivery System of Amphiphilic Jaspine B for Treatment of Synovial Sarcoma

Formulation, Characterization, and In Vitro/In Vivo Efficacy Studies of a Novel Liposomal Drug Delivery System of Amphiphilic Jaspine B for Treatment of Synovial Sarcoma

Sphingomyelin is a cell membrane sphingolipid that is upregulated in synovial sarcoma (SS). Jaspine B has been shown to inhibit sphingomyelin synthase, which synthesizes sphingomyelin from ceramide, a critical signal transducer; however, jaspine B’s low bioavailability limits its application as a pr...

Full description

Bibliographic Details
Main Authors: Sana Khajeh pour, Sameena Mateen, Srinath Pashikanti, Jared J. Barrott, Ali Aghazadeh-Habashi
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Marine Drugs
Subjects:
liposomes
jaspine B
microfluidic method
drug delivery
synovial sarcoma
Online Access:https://www.mdpi.com/1660-3397/20/8/509

Internet

https://www.mdpi.com/1660-3397/20/8/509

Similar Items