Formulation, Characterization, and In Vitro/In Vivo Efficacy Studies of a Novel Liposomal Drug Delivery System of Amphiphilic Jaspine B for Treatment of Synovial Sarcoma
Sphingomyelin is a cell membrane sphingolipid that is upregulated in synovial sarcoma (SS). Jaspine B has been shown to inhibit sphingomyelin synthase, which synthesizes sphingomyelin from ceramide, a critical signal transducer; however, jaspine B’s low bioavailability limits its application as a pr...
Main Authors: | Sana Khajeh pour, Sameena Mateen, Srinath Pashikanti, Jared J. Barrott, Ali Aghazadeh-Habashi |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-08-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/20/8/509 |
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