iPSC-Derived Hereditary Breast Cancer Model Reveals the <i>BRCA1</i>-Deleted Tumor Niche as a New Culprit in Disease Progression

iPSC-Derived Hereditary Breast Cancer Model Reveals the <i>BRCA1</i>-Deleted Tumor Niche as a New Culprit in Disease Progression

Tumor progression begins when cancer cells recruit tumor-associated stromal cells to produce a vascular niche, ultimately resulting in uncontrolled growth, invasion, and metastasis. It is poorly understood, though, how this process might be affected by deletions or mutations in the breast cancer typ...

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Bibliographic Details
Main Authors: Lucie Portier, Christophe Desterke, Diana Chaker, Noufissa Oudrhiri, Afag Asgarova, Fatima Dkhissi, Ali G. Turhan, Annelise Bennaceur-Griscelli, Frank Griscelli
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells
iPSC
BRCA1
breast cancer
angiogenesis
periostin
Online Access:https://www.mdpi.com/1422-0067/22/3/1227

Internet

https://www.mdpi.com/1422-0067/22/3/1227

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