Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.

Diabetic peripheral polyneuropathy is associated with decrements in motor/sensory neuron myelination, nerve conduction and muscle function; however, the mechanisms of reduced myelination in diabetes are poorly understood. Chronic elevation of oxidative stress may be one of the potential determinants...

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Bibliographic Details
Main Authors: Ryan T Hamilton, Arunabh Bhattacharya, Michael E Walsh, Yun Shi, Rochelle Wei, Yiqiang Zhang, Karl A Rodriguez, Rochelle Buffenstein, Asish R Chaudhuri, Holly Van Remmen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3672154?pdf=render

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http://europepmc.org/articles/PMC3672154?pdf=render

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