Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

Summary: Super killer (SKI) complex is a well-known cytoplasmic 3′–5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs, is implicated with the extraction of mRNA at stalled ribosomes, tackling aberrant translation. Here, we show that SKIV2L and TTC37 of the...

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Bibliographic Details
Main Authors: Emilia Herrera-Moyano, Rosa Maria Porreca, Lepakshi Ranjha, Eleni Skourti, Roser Gonzalez-Franco, Emmanouil Stylianakis, Ying Sun, Ruihan Li, Almutasem Saleh, Alex Montoya, Holger Kramer, Jean-Baptiste Vannier
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224023216

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http://www.sciencedirect.com/science/article/pii/S2589004224023216

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