The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia

Abstract Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological processes by specifically binding to substrates. PARP1 plays a role in cell ap...

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Bibliographic Details
Main Authors: Xinxin Lu, Xinyue Huang, Haiqi Xu, Saien Lu, Shilong You, Jiaqi Xu, Qianru Zhan, Chao Dong, Ning Zhang, Ying Zhang, Liu Cao, Xingang Zhang, Naijin Zhang, Lijun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01209-9

Internet

https://doi.org/10.1038/s41420-022-01209-9

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