Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling
Presenilin-1 (PS1) protein is the catalytic subunit of the gamma-secretase, and participates in the processing of beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm. NICD migrates to the nucleus and causes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/6/10.2741/4851 |