Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis after Traumatic Neuronal Injury

Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis after Traumatic Neuronal Injury

Despite medical advances, neurological recovery after severe traumatic brain injury (TBI) remains poor. Elevated levels of high mobility group box protein-1 (HMGB1) are associated with poor outcomes; likely via interaction with receptors for advanced-glycation-end-products (RAGE). We examined the hy...

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Bibliographic Details
Main Authors: Susruta Manivannan, Balkis Harari, Maryam Muzaffar, Omar Elalfy, Sameera Hettipathirannahelage, Zoe James, Feras Sharouf, Chloe Ormonde, Mouhamed Alsaqati, William Gray, Malik Zaben
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Brain Sciences
Subjects:
traumatic brain injury
neurogenesis
HMGB1
neuroinflammation
Online Access:https://www.mdpi.com/2076-3425/10/10/760

Internet

https://www.mdpi.com/2076-3425/10/10/760

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