Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA demethylation and report the results of a phase 1 t...

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Bibliographic Details
Main Authors: Alexei F. Kirkin, Karine N. Dzhandzhugazyan, Per Guldberg, Johnny Jon Fang, Rikke S. Andersen, Christina Dahl, Jann Mortensen, Tim Lundby, Aase Wagner, Ian Law, Helle Broholm, Line Madsen, Christer Lundell-Ek, Morten F. Gjerstorff, Henrik J. Ditzel, Martin R. Jensen, Walter Fischer
Format: Article
Language:English
Published: Nature Portfolio 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03217-9

Internet

https://doi.org/10.1038/s41467-018-03217-9

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