Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses

Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses

Abstract Hippocampus-dependent learning and memory originate from long-term synaptic changes in hippocampal networks. The activity of CA1 somatostatin interneurons (SOM-INs) during aversive stimulation is necessary for contextual fear memory formation. In addition, mTORC1-dependent long-term potenti...

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Bibliographic Details
Main Authors: Eve Honoré, Jean-Claude Lacaille
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Brain
Subjects:
Dorsal CA1 hippocampus
Somatostatin interneurons
Long-term potentiation
Object location memory
mTORC1
Optogenetic silencing
Online Access:https://doi.org/10.1186/s13041-022-00988-7

Internet

https://doi.org/10.1186/s13041-022-00988-7

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