Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes
γ-Secretase is a protease complex, which catalyzes the final of two subsequent cleavages of the β-amyloid precursor protein (APP) to release the amyloid-β peptide (Aβ) implicated in Alzheimer’s disease (AD) pathogenesis. In human cells, six γ-secretase complexes exist, which are composed of either p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-07-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996107000952 |