Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Abstract Background Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, its potential mechanism of its protective effects remains unclear. In this study, the protective mechanism of HKL on LPS-induced ALI was explored in vivo and in vitro...

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Bibliographic Details
Main Authors: Yuhan Liu, Jiabin Zhou, Yingying Luo, Jinxiao Li, Luorui Shang, Fangyuan Zhou, Shenglan Yang
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Chinese Medicine
Subjects:
Acute lung injury
Honokiol
NLRP3 inflammasome
Pyroptosis
Nrf2
Lipopolysaccharide
Online Access:https://doi.org/10.1186/s13020-021-00541-z

Internet

https://doi.org/10.1186/s13020-021-00541-z

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