LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF‐β1 in Parkinson's Disease

Abstract The gene mutations of LRRK2, which encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with one of the most prevalent monogenic forms of Parkinson's disease (PD). However, the potential effectors of the Gly2019Ser (G2019S) mutation remain unknown. In this study, the authors in...

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Bibliographic Details
Main Authors: Longping Yao, Fengfei Lu, Sumeyye Koc, Zijian Zheng, Baoyan Wang, Shizhong Zhang, Thomas Skutella, Guohui Lu
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
Online Access:https://doi.org/10.1002/advs.202303711